| Autor: |
Aghayan M; Dept. of Chemistry, Faculty of science, Islamic Azad University, North Tehran Branch, Tehran, Iran. mahmoudiali.ac@gmail.com., Mahmoudi A; Dept. of Chemistry, Faculty of science, Islamic Azad University, North Tehran Branch, Tehran, Iran. mahmoudiali.ac@gmail.com., Sazegar MR; Dept. of Chemistry, Faculty of science, Islamic Azad University, North Tehran Branch, Tehran, Iran. mahmoudiali.ac@gmail.com., Adhami F; Dep. of chemistry, Faculty of science, Islamic Azad University, Yadegar-e-Imam Khomeini (RAH), Shahre rey Branch, Tehran, Iran. |
| Jazyk: |
angličtina |
| Zdroj: |
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2021 Oct 05; Vol. 50 (38), pp. 13345-13356. Date of Electronic Publication: 2021 Oct 05. |
| DOI: |
10.1039/d1dt02084f |
| Abstrakt: |
In an attempt to explore the significance of inorganic mimetic enzymes as sensors, this study introduces a naked-eye analytical sensing platform for the detection of L-cysteine (cys), mercury ions (Hg 2+ ) based on (turn off/turn-on) catalytic activity of zinc and cobalt grafted mesoporous silica nanoparticles (MSNs). To this end, Zn-MSN and Co/Zn-MSN catalysts were synthesized and characterized using XRD, FT-IR, FESEM, TEM, and nitrogen adsorption-desorption methods. Then, using the intrinsic peroxidase-like activity of as-synthesized samples, the oxidation reactions of the chromogenic substrate (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS)) was designed using H 2 O 2 , which produced green colored cation radical of ABTS. Considering the high peroxidase-like activity of Co/Zn-MSN in comparison to Zn-MSN, it was employed to detect cys and then Hg 2+ . The results indicated that the strong interaction between cys and Co/Zn-MSN was proved by a limit of detection (LOD) down to 0.24 nM and the linear relationship from 0.8-50 nM (turn off). Given the fact that Hg 2+ has a high-affinity tendency to combine with cys, we were suggested a novel colorimetric path for sensing of Hg 2+ in the presence of cys (turn on). Based on this method, LOD was found 0.17 nM with the linear range of 0.57-50 nM. Taken together, results showed that the as-prepared catalysts are superior to other nanoparticles as a sensor to measure the target molecules in biological monitoring and clinical diagnostics. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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