Precisely timed theta oscillations are selectively required during the encoding phase of memory.

Autor: Quirk CR; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Zutshi I; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Srikanth S; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Fu ML; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Devico Marciano N; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Wright MK; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Parsey DF; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Liu S; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Siretskiy RE; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Huynh TL; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Leutgeb JK; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA., Leutgeb S; Neurobiology Section and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA. sleutgeb@ucsd.edu.; Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA, USA. sleutgeb@ucsd.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2021 Nov; Vol. 24 (11), pp. 1614-1627. Date of Electronic Publication: 2021 Oct 04.
DOI: 10.1038/s41593-021-00919-0
Abstrakt: Brain oscillations have been hypothesized to support cognitive function by coordinating spike timing within and across brain regions, yet it is often not known when timing is either critical for neural computations or an epiphenomenon. The entorhinal cortex and hippocampus are necessary for learning and memory and exhibit prominent theta oscillations (6-9 Hz), which are controlled by pacemaker cells in the medial septal area. Here we show that entorhinal and hippocampal neuronal activity patterns were strongly entrained by rhythmic optical stimulation of parvalbumin-positive medial septal area neurons in mice. Despite strong entrainment, memory impairments in a spatial working memory task were not observed with pacing frequencies at or below the endogenous theta frequency and only emerged at frequencies ≥10 Hz, and specifically when pacing was targeted to maze segments where encoding occurs. Neural computations during the encoding phase were therefore selectively disrupted by perturbations of the timing of neuronal firing patterns.
(© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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