Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications.

Autor: Orgul G; Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Turkey. Electronic address: gokcenorgul@gmail.com., Dalva K; Division of Haematology, Department of Internal Medicine, Ankara University, Turkey. Electronic address: klaradalva@gmail.com., Dalva-Aydemir S; Biotechnology Institute, Ankara University, Turkey. Electronic address: sevim.dalva@gmail.com., Alniacik RG; Division of Haematology, Department of Internal Medicine, Ankara University, Turkey. Electronic address: ridvan2000@gmail.com., Donmez HG; Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey. Electronic address: hnftnr@gmail.com., Cakar AN; Department of Histology and Embryology, TOBB University, Ankara, Turkey. Electronic address: ancakar@yahoo.com., Beksac M; Division of Haematology, Department of Internal Medicine, Ankara University, Turkey. Electronic address: mbeksac56@gmail.com., Beksac MS; Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Turkey. Electronic address: beksac@hacettepe.edu.tr.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2021 Nov; Vol. 148, pp. 103425. Date of Electronic Publication: 2021 Sep 21.
DOI: 10.1016/j.jri.2021.103425
Abstrakt: Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood. We aimed to demonstrate the association of maternal KIR-fetal KIR ligand genotype combinations with immunological/metabolic risk factor associated placenta-related obstetric complications. This study consisted of three groups of pregnant women: 1) Miscarriage group (n = 30), 2) Complicated Pregnancy (CP) group (n = 30), and 3) Control group (n = 30). The observed maternal genotype frequencies of all inhibitory and activating KIRs were similar in all groups (p > 0.05). However, inhibitory 2DL3 was quite frequent in the miscarriage group (p = 0.052). There was no difference between groups in terms of centromeric and telomeric maternal haplotypes (p > 0.05). The fetal group 1 HLA-C genotype was frequently detected in the miscarriage and CP groups with rates of 83.3 % and 93.3 % respectively, while the observed frequency was 70 % in the control group. The fetal group 2 HLA-C genotype was the same in all groups. The results demonstrated significantly less fetal group 2 HLA-C homozygosity in the CP groups when compared to the control group (p = 0.020). The fetal HLA-Bw4 genotype was detected more frequently in the miscarriage and CP groups (p = 0.028 and p = 0.001, respectively). The inhibitory KIR/KIR ligand genotype combinations of 2DL3-C1 and 3DL1-Bw4 were more frequent in the miscarriage and CP groups (p = 0.045 and p = 0.002, respectively). Enhanced NK cell inhibition may be one of the mechanisms underlying placenta-related obstetric complications.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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