Topical opioid use in dermatologic disease: A systematic review.
| Autor: | Gutierrez Y; School of Medicine, University of California Riverside, Riverside, California, USA., Pourali SP; School of Medicine, Vanderbilt University, Nashville, Tennessee, USA., Kucharik AH; Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA., Jones ME; Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Rajkumar JR; College of Medicine at Chicago, University of Illinois, Chicago, Illinois, USA., Armstrong AW; Keck School of Medicine, University of Southern California, Los Angeles, California, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Dermatologic therapy [Dermatol Ther] 2021 Nov; Vol. 34 (6), pp. e15150. Date of Electronic Publication: 2021 Oct 14. |
| DOI: | 10.1111/dth.15150 |
| Abstrakt: | Topical opioid formulations offer a potential solution to manage pain and decrease the use of systemic opioids. Synthesis of use and efficacy of topical opioids in dermatological conditions has not been well characterized. We conducted a systematic search of the PubMed, Embase, and Cochrane databases from 1980 to February 2021. This study analyzed data from 14 articles and 263 patients on the use of topical opioids for pain related to chronic ulcers, burns, oral lichen planus, photodynamic therapy, and split-thickness skin grafts. Topical opioids included in this review were topical morphine and diamorphine. Common formulations consisted of 0.2-10 mg of opioid compounded with hydrogel or IntraSite gel. Topical opioids were variably effective in the use for pain control related to chronic ulcers and other dermatologic conditions. For example, the use of topical opioids appears to be effective in the reduction of pain related to pressure ulcers. Topical opioids were generally well tolerated. Insufficient data exist to adequately evaluate the efficacy and safety of topical opioid use in the context of nonpressure ulcers, burns, oral lichen planus, photodynamic therapy, and split-thickness skin grafts. (© 2021 Wiley Periodicals LLC.) |
| Databáze: | MEDLINE |
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