Selection between Competing Self-Reproducing Lipids: Succession and Dynamic Activation.
| Autor: | Howlett MG; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Scanes RJH; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom., Fletcher SP; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | JACS Au [JACS Au] 2021 Aug 16; Vol. 1 (9), pp. 1355-1361. Date of Electronic Publication: 2021 Aug 16 (Print Publication: 2021). |
| DOI: | 10.1021/jacsau.1c00138 |
| Abstrakt: | Models of chemical evolution are central to advancing origins of life research. To design more lifelike systems, we must expand our understanding of molecular selection mechanisms. Here, we show two selection modes that produce evolving populations of self-reproducing species, formed through thiol-disulfide exchange. Competition between thiol precursors can give clear succession patterns based on steric factors, an intrinsic property. A separate, emergent selection mechanism-dynamic activating metathesis-was found when exploring competing disulfide precursors. These experiments reveal that additional species generated in the mixture open up alternative reaction pathways to form self-reproducing products. Thus, increased compositional complexity provides certain species with a unique competitive advantage at the expense of others. Competing Interests: The authors declare no competing financial interest. (© 2021 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|