Bariatric Surgery Improves Renal Function in Patients With Obesity.

Autor: Abernathy OL; Internal Medicine, Kansas University School of Medicine-Wichita, Wichita, USA., Okut H; Preventive Medicine, Kansas University School of Medicine-Wichita, Wichita, USA., Paull-Forney BG; Weight Management Clinic, Ascension Via Christi Hospital, Wichita, USA., Schwasinger-Schmidt TE; Internal Medicine, Kansas University School of Medicine-Wichita, Wichita, USA.
Jazyk: angličtina
Zdroj: Cureus [Cureus] 2021 Aug 26; Vol. 13 (8), pp. e17458. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021).
DOI: 10.7759/cureus.17458
Abstrakt: Background Obesity affects 93.3 million adults in the United States and is a predisposing factor for the development and progression of chronic kidney disease (CKD). The objective of this study is to examine the association between weight loss and renal function in participants undergoing bariatric surgery following a 12-week multidisciplinary, community-based weight loss program. Methodology This is a retrospective chart review of participants who voluntarily enrolled in a 12-week multidisciplinary weight loss program prior to bariatric surgery from 2009 to 2018. The primary outcome was to assess the association between weight loss and renal function in participants undergoing bariatric surgery. Secondary outcomes included changes in hemoglobin A1c, lipids, fasting glucose, and blood pressure. Results Among the 55 participants, baseline glomerular filtration rate (GFR) was 49 mL/min/m 2 , 80% were female, and the average baseline weight was 131 kg. At one-year post-intervention, 69% of patients improved in the CKD stage, with 45% of the participants improving from stage 3A to stage 2. GFR improved to 15 mL/min/1.73m 2 (p = 0.025), and there was a negative correlation (r s = -0.3556) between weight and GFR (p = 0.013). Participants with hyperlipidemia had a 12 mL/min/1.73m 2 rise in GFR, while participants without the diagnosis at one year had a 24 mL/min/1.73m 2 rise in GFR (p = 0.007). Conclusions This study demonstrated improved renal function and reduced progression of CKD following a combined lifestyle and surgical intervention, indicating the importance of a comprehensive approach for the management of the chronic disease.
Competing Interests: The authors have declared financial relationships, which are detailed in the next section.
(Copyright © 2021, Abernathy et al.)
Databáze: MEDLINE
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