Gender Characteristics of the Novel Coronavirus Infection (COVID-19) in Middle-Aged Adults.

Autor:	Nekaeva ES; Head of the Admission and Consultation Department, University Clinic; Specialist in Internal Diseases, University Clinic; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Bolshakova AE; Specialist in Assessing Pharmacological Prescriptions, Admission and Consultation Department, University Clinic; Associate Professor, Department of Pharmaceutical Chemistry and Pharmacognosy; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Malysheva ES; Assistant, Department of Endocrinology and Internal Medicine; Endocrinologist, Admission and Consultation Department, University Clinic; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Galova EA; Deputy Director for Science, University Clinic; Associate Professor, Department of Public Health and Healthcare; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Makarova EV; Associate Professor, Head of the Department of Propedeutics of Internal Diseases; Deputy Director for Academic Affairs, Institute of Internal Diseases; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Nekrasova TA; Associate Professor, Professor, Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Polyakova IV; Assistant, Vogralik Department of Advanced Internal Medicine and General Medical Practice; Specialist in Internal Diseases, Consultative and Diagnostic Department with Radiation Diagnostics and Day Hospital, University Clinic; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Bedretdinova ZS; Specialist in Internal Diseases, Consultative and Diagnostic Department with Radiation Diagnostics and Day Hospital, University Clinic; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Belikina DV; Assistant, Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Lavrenyuk AA; Student, Medical Faculty; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia., Fomin IV; Professor, Head of the Vogralik Department of Advanced Internal Medicine and General Medical Practice; Director of the Institute of Internal Diseases; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Jazyk:	angličtina
Zdroj:	Sovremennye tekhnologii v meditsine [Sovrem Tekhnologii Med] 2021; Vol. 13 (4), pp. 16-24. Date of Electronic Publication: 2021 Aug 28.
DOI:	10.17691/stm2021.13.4.02
Abstrakt:	The aim of the study is to assess the gender-related specifics of the COVID-19 course in patients under 55 years of age. Materials and Methods: This pilot single-center continuous retrospective non-randomized study was carried out in the repurposed infectious diseases hospital of the Privolzhsky Research Medical University (Nizhny Novgorod, Russia). The study inclusion criterion was the age of patients (up to 55 years) and confirmed coronavirus infection. In the groups based on gender differences (25 men, average age 44.0±7.8 years and 32 women, average age 41.9±9.1 years), we monitored complications of COVID-19 such as the transfer of patients to the ICU and the volume of lung damage (determined with CT scans). Results: The course of COVID-19 in male patients younger than 55 was aggravated by concomitant diseases (γ=0.36; p=0.043), among which IHD (γ=1.00; p=0.003) and liver disease (γ=0.58; p=0.007) dominated. Frequency analysis confirmed the high prevalence of coronary artery disease in men (p=0.044). Significant differences between the gender-related groups were noted in the volume of lung lesions: at admission (p=0.050), during hospital treatment (p=0.019), and at discharge (p=0.044). Using the logistic regression method, a relationship was found between the transfer of male patients to ICU and the Krebs index [y= -2.033 + 1.154 male gender + 1.539 Krebs index (χ 2 =5.68; p=0.059)] and comorbidity [y= -2.836 + 1.081 male gender + 2.052 comorbidity (χ 2 =7.03; p=0.030)]. The influence of the Krebs index and the male gender on the excess volume of lung lesions was shown [y= -1.962 + 0.575 male gender + 1.915 Krebs index (χ 2 =7.78; p=0.021)]. Conclusion: In individuals under the age of 55 diagnosed with COVID-19, gender is of significant importance: in men, there is a more pronounced lesion of the lung parenchyma and a more significant change in laboratory parameters. Risk factors for a severe course of COVID-19 in men are coronary artery disease and hepatobiliary disorder. Calculating the Krebs index can be used to assess the risk of disease progression. Competing Interests: Conflicts of interest. This work, its theme, subject, and content do not involve conflict of interests.
Databáze:	MEDLINE
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