Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections.

Autor:	Humphries DC; Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom.; Sanofi Pasteur, R&D, Marcy l'Etoile, Lyon, France., O'Connor RA; Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Larocque D; Sanofi Pasteur, R&D, Marcy l'Etoile, Lyon, France., Chabaud-Riou M; Sanofi Pasteur, R&D, Marcy l'Etoile, Lyon, France., Dhaliwal K; Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh BioQuarter, The University of Edinburgh, Edinburgh, United Kingdom., Pavot V; Sanofi Pasteur, R&D, Marcy l'Etoile, Lyon, France.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Sep 17; Vol. 12, pp. 738955. Date of Electronic Publication: 2021 Sep 17 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.738955
Abstrakt:	There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent state, constantly surveying the lung for microbial intruders. Upon reactivation with cognate antigen, these cells provide rapid effector function to enhance immunity and prevent infection. Immunization strategies designed to induce their formation, alongside novel techniques enabling their detection, have the potential to accelerate and transform vaccine development. Despite most data originating from murine studies, this review will discuss recent insights into the generation, maintenance and characterisation of pulmonary resident memory lymphocytes in the context of respiratory infection and vaccination using recent findings from human and non-human primate studies. Competing Interests: KD is a founder and shareholder of Edinburgh Molecular Imaging. DH, DL, MC-R and VP were employed by Sanofi Pasteur. The authors declare that this study received funding from Sanofi Pasteur. The funder had the following involvement in the study: study design, preparation of the manuscript and decision to publish. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Humphries, O’Connor, Larocque, Chabaud-Riou, Dhaliwal and Pavot.)
Databáze:	MEDLINE
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