MOTHER Study: A M ulticenter O bservational, Retrospective S t udy to Determine Coorelation Between Physical C H aracteristics and Ovarian R E serve Markers in Sub-fe R tile Women.

Autor: Ayyavoo C; Parvathy Ayyavoo Fertility Centre, Aditi Hospital, 5, Usman Ali Street, TVS Tolgate, Trichy, Tamil Nadu 620020 India., Baxi A; Disha Fertility and Surgical Centre, E-30, Saket Nagar, Indore, Madhya Pradesh 452018 India., Mandrupkar G; Mandrupkar Clinic, More Nagar, Near ST Stand, Islampur (Dist- Sangli), Maharashtra 415409 India., Malik S; Southend Fertility and IVF, Max Smart Super Speciality Hospital, Press Enclave Road, Malviya Nagar, Saket, New Delhi, 110017 India., Kannan J; Garbba Rakshambigai Fertility Center, Jayam Hospital, No. 4, 6th Cross Street, United India Colony, Kodambakkam, Chennai, Tamil Nadu 600024 India., Goenka D; Institute of Human Reproduction, Bharalumukh, Guwahati, Assam 781009 India., Kumar N; Janani Hospital and IVF Centre, Gandhi Nagar, Tumkur, Karnataka 572101 India., Singh M; Bhopal Test-Tube-Baby and Endoscopy Centre, E-1/13A, Arera Colony, Near No. 7 Stop, Bhopal, Madhya Pradesh 462016 India., Kulkarni S; Siddhilife Assisted Reproduction Center, A Wing 101, First floor, Mrud Kishore Building Dattapada Phatak Road, Off S.V.Road, Borival West Mumbai, 40009 India., Agarwal KM; Institute of Human Reproduction, Bharalumukh, Guwahati, Assam 781009 India., Baxi S; Disha Fertility and Surgical Centre, E-30, Saket Nagar, Indore, Madhya Pradesh 452018 India.
Jazyk: angličtina
Zdroj: Journal of obstetrics and gynaecology of India [J Obstet Gynaecol India] 2021 Oct; Vol. 71 (5), pp. 510-521. Date of Electronic Publication: 2021 May 08.
DOI: 10.1007/s13224-020-01410-9
Abstrakt: Background: The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India.
Methods: In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected.
Results: Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation.
Conclusion: Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Federation of Obstetric & Gynecological Societies of India 2021.)
Databáze: MEDLINE
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