REPORT-Association analysis of STAT6 SNP with asthma in Pakistani population.
| Autor: | Riaz A; Centre for Applied Molecular Biology, Ministry of Sciences and Technology, 87 West Canal Bank Road, Thokar Niaz Baig, Lahore, Pakistan., Akhter Z; Centre for Applied Molecular Biology, Ministry of Sciences and Technology, 87 West Canal Bank Road, Thokar Niaz Baig, Lahore, Pakistan., Iqbal M; Centre for Applied Molecular Biology, Ministry of Sciences and Technology, 87 West Canal Bank Road, Thokar Niaz Baig, Lahore, Pakistan., Ahsan Riaz M; Department of Environmental Sciences and Engineering, Government College University, Faisalabad, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2021 May; Vol. 34 (3), pp. 1019-1022. |
| Abstrakt: | Signal transducer and activator of transcription 6 gene (STAT6) is an important player of inflammatory pathways. The role of single nucleotide polymorphisms (SNPs) of STAT6 to the risk of asthma or IgE has been studied in several populations. We examined STAT6 SNP in relation to asthma risk among Pakistani individuals, suffering from asthma. We genotyped STAT6 SNP rs1059513 using SNaPshot minisequencing assay. SNP association analysis was statistically confirmed by linkage disequilibrium calculator and online SHEsis software. Significance of differences between asthmatics and control group was tested for genotypes and allele frequencies. Our results indicated that STAT6 polymorphism rs1059513 has no association with asthma in Pakistani population as any difference in allele frequency and genotype was not observed between asthmatics and controls. The present study to date is very first of genetic variation in STAT6 and asthma risk, designed for evidence of the STAT6 involvement in asthma risk in Pakistani population. |
| Databáze: | MEDLINE |
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