Design, synthesis, and molecular docking study of some 2-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff bases as potential Eg5 inhibitory agents.

Autor: Kavalapure RS; Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India., Alegaon SG; Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India. Electronic address: sgalegaon@klepharm.edu., Venkatasubramanian U; School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613 401, India., Priya AS; School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613 401, India., Ranade SD; Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India., Khanal P; Department of Pharmacology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi 590010, India., Mishra S; KAHER's Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Belagavi 590010, Karnataka, India., Patil D; KAHER's Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Belagavi 590010, Karnataka, India., Salve PS; Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India., Jalalpure SS; KAHER's Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, Belagavi 590010, Karnataka, India; Department of Pharmacognosy, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi 590 010, Karnataka, India.
Jazyk: angličtina
Zdroj: Bioorganic chemistry [Bioorg Chem] 2021 Nov; Vol. 116, pp. 105381. Date of Electronic Publication: 2021 Sep 24.
DOI: 10.1016/j.bioorg.2021.105381
Abstrakt: In Search of new microtubule-targeting compounds and to identify a promising Eg5 inhibitory agents, a series of 2-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff bases molecules (6 a-r) were synthesized using appropriate synthetic method. The synthesized compounds were characterized by using FTIR, Proton NMR, Carbon NMR and mass spectral analysis. All eighteen compounds were evaluated for their Eg5 inhibitory activity. Among the evaluated compounds, only seven compounds are shown inhibitory activity. The results of Steady state ATPase reveled that compounds 6b, 6l and 6p exhibited promising inhibitory activity with IC 50 Values of 2.720 ± 0.69, 2.676 ± 0.53 and 2.408 ± 0.46 respectively. Malachite Green Assay results reveled that 6q compound showed better inhibitory activity with IC 50 Value of 0.095 ± 0.27. In vitro antioxidant capacity of the synthesized compounds was investigated. A molecular docking studies were performed to evaluate interaction in to binding site of kinesin spindle protein, these interaction influencing may support Eg5 inhibitory activity. The drug like parameters of the eighteen synthesized compounds were also computed using Qikprop software. In conclusion, some of 2-((7-chloroquinolin-4-yl) amino) benzohydrazide Schiff base compounds represent promising drug like agents for discovery of effective anticancer molecules.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: