Unusual intra-rectal "laterally spreading tumour" in immunosuppressed patient with ulcerative colitis.
| Autor: | Vieujean S; Department of Gastroenterology, Liege, Belgium., Latour P; Department of Gastroenterology, Liege, Belgium., Coimbra C; Department of Abdominal Surgery, Liege, Belgium., Delvenne P; Department of Anatomopathology Liège, Belgium., Louis E; Department of Gastroenterology, Liege, Belgium., Van Kemseke C; Department of Gastroenterology, Liege, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Acta gastro-enterologica Belgica [Acta Gastroenterol Belg] 2021 Jul-Sep; Vol. 84 (3), pp. 509-512. |
| DOI: | 10.51821/84.3.018 |
| Abstrakt: | Condyloma acuminatum (CA) is a manifestation of Human Papillomavirus (HPV) infection which usually occurs in genital and perianal regions. We report a 46-year-old man with an ulcerative proctitis diagnosed four years earlier, asymptomatic for a long time under azathioprine but without any follow-up for three years. A colonoscopy was performed prior to potential immunosuppressive treatment discontinuation and showed a circumferential "laterally spreading tumour" in the rectum. Surprisingly biopsies revealed a CA with a very focally high-grade intra-epithelial lesion. Azathioprine was stopped and a transanal surgical resection was performed. At guided anamnesis, patient confirmed to be a former active "men who have sex with men". No recurrence of proctitis occurred despite azathioprine discontinuation. A retrospective review of the histological sections suggests that it was, in fact, an intestinal spirochetosis misdiagnosed as inflammatory bowel disease. Involvement of the rectal mucosa by HPV is a rare condition and this may have been promoted by inappropriate immunosuppressive treatment. Competing Interests: The authors declare that they have no conflict of interest (© Acta Gastro-Enterologica Belgica.) |
| Databáze: | MEDLINE |
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