Factors modulating the incubation of drug and non-drug craving and their clinical implications.

Autor: Venniro M; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, USA. Electronic address: marco.venniro@som.umaryland.edu., Reverte I; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy; Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy., Ramsey LA; Behavioral Neuroscience Research Branch, Intramural Research Program, Baltimore NIDA, NIH, USA., Papastrat KM; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, USA., D'Ottavio G; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy; Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy., Milella MS; Toxicology Unit, Policlinico Umberto I University Hospital, Rome, Italy., Li X; Department of Psychology, University of Maryland College Park, College Park, USA. Electronic address: annali@umd.edu., Grimm JW; Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, USA. Electronic address: grimmj@wwu.edu., Caprioli D; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy; Santa Lucia Foundation (IRCCS Fondazione Santa Lucia), Rome, Italy. Electronic address: daniele.caprioli@uniroma1.it.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2021 Dec; Vol. 131, pp. 847-864. Date of Electronic Publication: 2021 Sep 28.
DOI: 10.1016/j.neubiorev.2021.09.050
Abstrakt: It was suggested in 1986 that cue-induced cocaine craving increases progressively during early abstinence and remains high during extended periods of time. Clinical evidence now supports this hypothesis and that this increase is not specific to cocaine but rather generalize across several drugs of abuse. Investigators have identified an analogous incubation phenomenon in rodents, in which time-dependent increases in cue-induced drug seeking are observed after abstinence from intravenous drug or palatable food self-administration. Incubation of craving is susceptible to variation in magnitude as a function of biological and/or the environmental circumstances surrounding the individual. During the last decade, the neurobiological correlates of the modulatory role of biological (sex, age, genetic factors) and environmental factors (environmental enrichment and physical exercise, sleep architecture, acute and chronic stress, abstinence reinforcement procedures) on incubation of drug craving has been investigated. In this review, we summarized the behavioral procedures adopted, the key underlying neurobiological correlates and clinical implications of these studies.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: