The effect of local anaesthetic on delayed bleeding in a epigastric flap model of rats.
| Autor: | Tapan M; Department of Plastic, Reconstructive and Aesthetic Surgery, Akdeniz University, Antalya, Turkey., Ünlü RE; Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara City Hospital Bilkent, Ankara, Turkey., İğde M; Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara City Hospital Bilkent, Ankara, Turkey., Tapan YU; Deparment of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey., Öztürk MO; Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir Çiğli Regional Education Hospital, Izmir, Turkey., Tekindal MA; Department of Biostatics, Selçuk University, Konya, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of wound care [J Wound Care] 2021 Sep 02; Vol. 30 (Sup9a), pp. IIi-IIv. |
| DOI: | 10.12968/jowc.2021.30.Sup9a.II |
| Abstrakt: | Objective: Local anaesthetics are often used in plastic surgery practice. Through their mechanism of action, local anaesthetics produce a sympathetic blockage with a subsequent vasodilatation and a resulting local increase of perfusion. The effect of vasodilation of the local anaesthetics causes bleeding locally resulting in haematoma, bruising and/or pain. We present an experimental study of the effects of local anaesthetics on delayed bleeding. Method: In this animal study, 36 adult male Wistar rats were divided into four groups of nine animals: lidocaine; lidocaine and epinephrine; bupivacaine; and control. An epigastric flap model was harvested. Local anaesthetics that are frequently used in daily practice were administered in equal amounts to the harvested flap. Results: After 24 hours, the rats were euthanised to collect and measure all coagula under the epigastric flap. No statistically significant differences in relation to the amount of coagulum were found between the groups. Conclusion: Our results suggest that proper haemostasis is achieved, there is no difference on the effect of delayed bleeding between the local anaesthetics which are often used. |
| Databáze: | MEDLINE |
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