Cost Analysis of R-CHOP Versus Dose-Adjusted R-EPOCH in Treatment of Diffuse Large B-Cell Lymphoma with High-Risk Features.

Autor: Dholaria B; Department of Hematology-Oncology, Pierce Ave, Preston Research Building, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA., Vanegas YAM; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.; Department of Internal Medicine, St. Elizabeth Medical Center, Boston, MA, USA., Diehl N; Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA., Spaulding AC; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, USA., Visscher S; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA., Tun HW; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA., Ailawadhi S; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA., Vishnu P; Department of Hematology and Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.; Harrison Health Partners Hematology and Oncology, Bremerton, WA, USA.
Jazyk: angličtina
Zdroj: Clinical hematology international [Clin Hematol Int] 2020 Apr 23; Vol. 2 (3), pp. 117-124. Date of Electronic Publication: 2020 Apr 23 (Print Publication: 2020).
DOI: 10.2991/chi.d.200410.001
Abstrakt: Dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA.R-EPOCH) is used for upfront treatment of high-risk diffuse large B cell lymphoma (DLBCL). In this study, we compared the outcomes in patients with high-risk DLBCL who received frontline rituximab, cycophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) or DA.R-EPOCH immunochemotherapy. Outcomes and treatment-related cost were analyzed. DLBCL with one of the following features were included in the study: MYC ± BCL2 or BCL6 rearrangement by FISH or MYC overexpression by immunohistochemistry, Ki67 index ≥ 80% or nongerminal center immunophenotype, tumor measuring ≥5 cm and NCCN- IPI score ≥4. A total of 80 patients were treated with R-CHOP ( n = 52, 65%) or DA.R-EPOCH ( n = 28, 35%), with a median follow-up of 11.2 months (range: 0.7-151.3 months). The hazard ratios (HRs) for progression-free survival and overall survival were 0.79 [95% confidence interval (CI) 0.28%-2.29%, p = 0.67] and 0.86 (95% CI 0.26%-2.78%, p = 0.80), respectively for DA.R-EPOCH compared to R-CHOP. The total mean cost was USD106,940 ± USD39,351 and USD58,509 ± 24,588 for DA.R-EPOCH and R-CHOP respectively ( p < 0.001). In our analysis, DA.R-EPOCH resulted comparable clinical outcomes and increased treatment-related expenses compared to R-CHOP in high-risk DLBCL.
Competing Interests: The authors delcare they have no conflicts of interest the final article.
(© 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.)
Databáze: MEDLINE
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