| Autor: |
Behroozi Z; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Rahimi B; Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Kookli K; International campus, Iran University of Medical Sciences, Tehran, Iran., Safari MS; Veterinary Faculty of Science and Research Branch, Islamic Azad University, Tehran, Iran., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa., Razmgir M; Medical Librarianship and Information Science, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran., Janzadeh A; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran., Ramezani F; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. |
| Abstrakt: |
Despite the widespread use of gold nanoparticles (GNPs), there is no consensus on their distribution to different tissues and organs. The present systematic review and meta-analysis addresses the accumulation of GNPs in brain tissue. Extensive searches were conducted in electronic databases, Medline, Web of Science, EMBASE, and Scopus. Based on inclusion and exclusion criteria, primary and secondary screening was performed. The value of brain accumulation of gold nanoparticle (the percentage of the injection dose of GNPs/gram of brain tissue that applied as effect size (ES) in analysis) and the standard error of the mean were extracted from articles and analyzed by calculating the pooled ES and the pooled confidence interval (CI) using STATA software. p ≤ 0.05 was considered significant. Thirty-eight studies were included in the meta-analysis. The results showed that the amount of GNPs was 0.06% of the injection dose/gram of brain tissue (ES = 0.06, %95 CI: 0.06-0.06, p < 0.0001). Considering the time between injection and tissue harvest (follow-up time), after 1 h the GNPs in brain tissue was 0.288% of the injection dose/gram of tissue (ES = 0.29, 95% CI: 0.25-0.33, p < 0.0001), while after four weeks it was only 0.02% (ES = 0.02, 95% CI: 0.01-0.03, p < 0.0001) of the injection dose/gram of tissue. The amount of GNPs in brain tissue was higher for PEG-coated GNPs compared to uncoated GNPs, and it was 5.6 times higher for rod-shaped GNPs compared to spherical GNPs. The mean amount of GNPs in the brain tissues of animals bearing a tumor was 5.8 times higher than in normal animals. |
