Expression pattern of MRPS18 family genes in gliomas.

Autor:	Kovalevska LM; R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv 03022, Ukraine., Malysheva TA; The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine., Kalman SS; R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv 03022, Ukraine., Rozumenko AV; The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine., Verbova LV; The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine., Rozumenko VD; The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine., Kashuba EV; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm S-17177, Sweden.
Jazyk:	angličtina
Zdroj:	Experimental oncology [Exp Oncol] 2021 Sep; Vol. 43 (3), pp. 204-208.
DOI:	10.32471/exp-oncology.2312-8852.vol-43-no-3.16461
Abstrakt:	Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest - for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.
Databáze:	MEDLINE
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