A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV-Vis spectroscopy.

Autor: de Oliveira LN; Instituto Federal de Educação, Ciência e Tecnologia de Goiás-IFG, Rua 75, 46, Campus Goiânia, Goiânia, GO, 74055-110, Brazil. lucas@ifg.edu.br.; Instituto de Pesquisas Energéticas e Nucleares, Comissão Nacional de Energia Nuclear-IPEN/CNEN, Av. Prof. Lineu Prestes, 2242, São Paulo, SP, 05508-000, Brazil. lucas@ifg.edu.br., do Nascimento EO; Instituto Federal de Educação, Ciência e Tecnologia de Goiás-IFG, Rua 75, 46, Campus Goiânia, Goiânia, GO, 74055-110, Brazil., Caldas LVE; Instituto de Pesquisas Energéticas e Nucleares, Comissão Nacional de Energia Nuclear-IPEN/CNEN, Av. Prof. Lineu Prestes, 2242, São Paulo, SP, 05508-000, Brazil.
Jazyk: angličtina
Zdroj: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2021 Nov; Vol. 20 (11), pp. 1381-1395. Date of Electronic Publication: 2021 Sep 30.
DOI: 10.1007/s43630-021-00088-w
Abstrakt: Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra (Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an irradiator containing a blue LED bulb lamp was utilized. The CHS samples were irradiated with ten doses from 0.60 up to 6.0 kJ/cm 2 , and six concentrations were prepared (1, 2, 3, 4, 5, and 6 mg/ml) for the CHS detector samples. After irradiation, the detector samples were evaluated using UV-Vis spectrophotometry. The results showed the behavior of the CHS detector with doses and concentrations, its sensitivity, and its linearity was also evaluated both by Wavelength Method (WM) and the Kernel Principal Component Regression (KPCR) Statistical Method. The values obtained indicate that this method can be applied to the CHS sample detector. In conclusion, the CHS is a promising detector in the field of photodynamic therapy.
(© 2021. The Author(s), under exclusive licence to European Photochemistry Association, European Society for Photobiology.)
Databáze: MEDLINE
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