IMMUNOGENICITY AND IMPACT ON NASOPHARYNGEAL CARRIAGE OF A SINGLE DOSE OF PCV10 GIVEN TO VIETNAMESE CHILDREN AT 18 MONTHS OF AGE.

Autor:	Higgins RA; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Temple B; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Global Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.; Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK., Dai VTT; Microbiology and Immunology, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Phan TV; Microbiology and Immunology, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Toan NT; Department of Disease Control and Prevention, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Spry L; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Toh ZQ; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Nation ML; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Ortika BD; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Uyen DY; Department of Disease Control and Prevention, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Cheung YB; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore.; Centre for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland., Nguyen CD; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia., Bright K; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Hinds J; Institute for Infection and Immunity, St George's, University of London, London, UK.; BUGS Bioscience, London Bioscience Innovation Centre, London, UK., Balloch A; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia., Smith-Vaughan H; Global Health, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia., Huu TN; Department of Disease Control and Prevention, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Mulholland K; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.; Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK., Satzke C; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia., Licciardi PV; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
Jazyk:	angličtina
Zdroj:	The Lancet regional health. Western Pacific [Lancet Reg Health West Pac] 2021 Sep 20; Vol. 16, pp. 100273. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).
DOI:	10.1016/j.lanwpc.2021.100273
Abstrakt:	Background: This study investigated the immunogenicity and impact on nasopharyngeal carriage of a single dose of PCV10 given to 18-month-old Vietnamese children. This information is important for countries considering catch-up vaccination during PCV introduction and in the context of vaccination during humanitarian crises. Methods: Two groups of PCV-naïve children within the Vietnam Pneumococcal Project received PCV10 (n=197) or no PCV (unvaccinated; n=199) at 18 months of age. Blood samples were collected at 18, 19, and 24 months of age, and nasopharyngeal swabs at 18 and 24 months of age. Immunogenicity was assessed by measuring serotype-specific IgG, opsonophagocytosis (OPA) and memory B cells (Bmem). Pneumococci were detected and quantified using real-time PCR and serotyped by microarray. Findings: At 19 months of age, IgG and OPA responses were higher in the PCV10 group compared with the unvaccinated group for all PCV10 serotypes and cross-reactive serotypes 6A and 19A. This was sustained out to 24 months of age, at which point PCV10-type carriage was 60% lower in the PCV10 group than the unvaccinated group. Bmem levels increased between 18 and 24 months of age in the vaccinated group. Interpretation: We demonstrate strong protective immune responses in vaccinees following a single dose of PCV10 at 18 months of age, and a potential impact on herd protection through a substantial reduction in vaccine-type carriage. A single dose of PCV10 in the second year of life could be considered as part of catch-up campaigns or in humanitarian crises to protect children at high-risk of pneumococcal disease. Competing Interests: Funding for this study was provided by grants from National Health and Medical Research Council of Australia (NHMRC) and/or Bill & Melinda Gates Foundation grants. Non-financial support (in the form of PCV10 vaccine doses) and funding for opsonophagocytic assays were provided by GSK Biologicals SA. KM, CS and CDN have received grant funding for a collaborative study on PCV impact on adult pneumonia from Pfizer. None of the authors have any other competing interests to declare. (© 2021 The Author(s). Published by Elsevier Ltd.)
Databáze:	MEDLINE
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