Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod: Role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines.

Autor: Tauil CB; Department of Medical Sciences, University of Brasília, Brazil., da Rocha Lima AD; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil., Ferrari BB; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil., da Silva VAG; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil., Moraes AS; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil., da Silva FM; Department of Psychology, Brasília District Hospital, Brazil., Melo-Silva CA; Department of Medical Sciences, University of Brasília, Brazil., Farias AS; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), CNPq, Brazil., Brandão CO; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil., Leonilda MBD; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Biology Institute, University of Campinas, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), CNPq, Brazil., Dos Santos-Neto LL; Department of Medical Sciences, University of Brasília, Brazil.
Jazyk: angličtina
Zdroj: Brain, behavior, & immunity - health [Brain Behav Immun Health] 2020 Oct 23; Vol. 9, pp. 100162. Date of Electronic Publication: 2020 Oct 23 (Print Publication: 2020).
DOI: 10.1016/j.bbih.2020.100162
Abstrakt: Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid precursor of serotonin and melatonin. It has been suggested that IDO is the link between the immune and serotonergic systems. This study aimed to quantify the levels of IDO and pro-inflammatory and anti-inflammatory cytokines in patients with MS and depression, according to treatment with interferon-beta (IFN-β) or fingolimod. The study inclusion criteria were age 18-60 years and a clinical and radiological diagnosis of MS. One hundred and thirty-two patients diagnosed by McDonald's criteria and followed up at Brasília District Hospital, Brazil, with relapsing-remitting MS were identified as potential study participants. Thirty-five of these patients were identified to be receiving treatment with fingolimod or IFN-β and to have a diagnosis of D/A. IDO and pro-inflammatory and anti-inflammatory cytokine levels were compared between these 35 patients and 18 healthy controls. The level of IL-10 (an anti-inflammatory cytokine) was lower in both the fingolimod-treated ( P  ​< ​0.001) and IFN-β-treated ( P  ​< ​0.01) patient groups than in the control group. IFN-β-treated patients showed increased IDO expression and decreased inflammatory cytokine levels. In contrast, fingolimod-treated patients showed significantly decreased expression of IDO and significantly increased levels of proinflammatory cytokines produced by innate immune cells, including tumor necrosis factor-alpha and interleukin-6. The agents used to treat MS maintain symptoms of D/A in patients with MS via different mechanisms.
Competing Interests: None.
(© 2020 The Authors.)
Databáze: MEDLINE
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