Secondary prevention of silicosis and silico-tuberculosis by periodic screening of silica dust exposed workers using serum club cell protein 16 as a proxy marker.

Autor: Sarkar K; Director ICMR - National Institute of Occupational Health Ahmedabad India., Dhatrak S; Department of Poison Information Center ICMR-National Institute of Occupational Health Ahmedabad India., Sarkar B; Department of Community Medicine Kalinga Institute of Medical Sciences Bhubaneswar India., Ojha UC; Department of Pulmonary Medicine ESIC PGIMSR & Hospital New Delhi India., Raghav P; Department of Community Medicine & Family Medicine All India Institute of Medical Sciences Jodhpur India., Pagdhune A; Department of Biochemistry Tata Memorial Centre Advanced Centre for Treatment, Research and Education in Cancer Navi Mumbai India.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2021 Sep 22; Vol. 4 (3), pp. e373. Date of Electronic Publication: 2021 Sep 22 (Print Publication: 2021).
DOI: 10.1002/hsr2.373
Abstrakt: Background and Objectives: Silicosis is a neglected and widely prevalent occupational disease in India and several other countries such as China, South Africa, Brazil, etc. It is an irreversible, incurable, and progressive disease with high morbidity and mortality, which is mostly caused by occupational exposure to silica dusts. Silicosis is usually detected at an advanced stage, when effective intervention is not possible. But early detection appears to be a cost-effective way to control it. There is a need for some suitable biomarker, which could detect silicosis at an early stage for further necessary intervention. This study aimed to estimate the lung damage in silicotic subjects and its relationship with serum CC16 as a proxy marker. The ultimate objective was to explore whether CC16 could be used as a screening tool for early detection of silicosis.
Methodology: Radiographs of 117 workers having radiological evidences of silicosis were evaluated in accordance with International Labour Organisation (ILO) Classification of chest radiographs and were categorized as mild, moderate, and severe lung damage using a lung damage scoring system, made for the purpose of this study. The concentration of CC16 in serum was determined by enzyme-linked immunosorbent assay.
Result: It was observed that serum CC16 values were significantly decreased in relation to increasing lung damage. The mean ± standard deviation (SD) serum CC16 value in mild lung damage group was 8.4 ± 0.87 ng/mL as compared to 4.0 ± 2.10 ng/mL in moderate and 0.7 ± 0.21 ng/mL in high lung damage groups. On the other hand, CC16 value of control (healthy) population was found to be 16.3 ± 3.8 ng/mL.
Conclusion: Result of the study concluded that serum CC16 might be used as a periodic screening tool for early detection of silicosis and for it's secondary prevention. It may be viewed as a new approach toward control of silicosis, and an appropriate policy may be adopted.
Competing Interests: The provision of financial support does not in any way infer or imply endorsement of the research findings by either agency. The authors declare no conflict of interest relating to the material presented in this article. Its contents, including any opinions and/or conclusions expressed, are solely those of the authors.
(© 2021 ICMR‐National Institute of Occupational Health. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE