Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants.

Autor:	Lugli L; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., Bedetti L; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy.; PhD Program in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy.; Pediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Guidotti I; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., Pugliese M; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy.; Psychology Unit, University Hospital of Modena and Reggio Emilia, Modena, Italy., Picciolini O; Physical and Rehabilitation Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Roversi MF; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., DellaCasa Muttini E; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., Lucaccioni L; Pediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Bertoncelli N; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., Ancora G; Neonatal Intensive Care Unit, Infermi Hospital of Rimini, Rimini, Italy., Gargano G; Neonatal Intensive Care Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy., Mosca F; Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Sandri F; Neonatal Intensive Care Unit, Maggiore Hospital of Bologna, Bologna, Italy., Corvaglia LT; Neonatal Intensive Care Unit, Sant'Orsola Malpighi University Hospital of Bologna, Bologna, Italy., Solinas A; Neonatal Intensive Care Unit, Sant'Anna Hospital of Ferrara, Ferrara, Italy., Perrone S; Neonatal Intensive Care Unit, University Hospital of Parma, Parma, Italy., Stella M; Neonatal Intensive Care Unit, Bufalini Hospital of Cesena, Cesena, Italy., Iughetti L; Pediatric Unit, Department of Medical and Surgical Sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.; Department of Medical and Surgical Sciences of Mothers, Children and Adults, Pediatric Postgraduate School, University of Modena and Reggio Emilia, Modena, Italy., Berardi A; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy., Ferrari F; Neonatal Intensive Care Unit, University Hospital of Modena, Modena, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Sep 13; Vol. 9, pp. 697100. Date of Electronic Publication: 2021 Sep 13 (Print Publication: 2021).
DOI:	10.3389/fped.2021.697100
Abstrakt:	Background: Despite the increased survival of preterm newborns worldwide, the risk of neurodevelopmental disabilities remains high. Analyzing the outcomes of the preterm population can identify risk factors and enable specific early interventions. Aims: Neuroprem is a prospective cohort study of very low birth weight (VLBW) infants that aims to evaluate the neurodevelopmental outcomes and risk factors for severe functional disability at 2 years of corrected age. Methods: Nine Italian neonatal intensive care units participated in the network. The Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and a neuro-functional evaluation (according to the International Classification of Disability and Health and Neuro-Functional Assessment, or NFA ICF-CY) were administered to VLBW infants at 24 months of corrected age. The primary outcome measure was severe functional disability, defined as cerebral palsy, bilateral blindness, deafness, an NFA ICF-CY of >2, a BSDI III cognitive composite score of <2 SD, or a GMDS-R global quotient score of <2 SD. Perinatal risk factors for severe functional disability were assessed through multivariate logistic regression analysis. Results: Among 502 VLBW survivors who completed the 24-month follow-up, 48 (9.6%) presented severe functional disability, of whom 27 had cerebral palsy (5.4%). Rates of severe functional disability and cerebral palsy were higher in neonates with a lower gestational age ( p < 0.001). Overall, 147 infants (29.3%) were referred to neuromotor intervention. In the multivariate regression model, gestational age at birth OR 0.79; 95% CI 0.67-0.90; p = 0.001) and periventricular-intraventricular hemorrhage (OR 2.51; 95% CI 1.19-5.26; p = 0.015) were significantly associated with severe functional disability. Conclusion: Neuroprem 2 provides updated information on the neurodevelopmental outcomes of VLBW infants in a large Italian cohort. The overall rate of neurodevelopmental disabilities was quite lower than reported in the previous literature. These data indicate the need for structured follow-up programs from a national neonatal network perspective. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Lugli, Bedetti, Guidotti, Pugliese, Picciolini, Roversi, DellaCasa Muttini, Lucaccioni, Bertoncelli, Ancora, Gargano, Mosca, Sandri, Corvaglia, Solinas, Perrone, Stella, The Neuroprem Working Group, Iughetti, Berardi and Ferrari.)
Databáze:	MEDLINE
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