A Rare Case of Clear Cell Cervical Carcinoma to a Woman, 50 Years After Diethylstilbestrol Exposure for Lactation Suppression.
| Autor: | Palaiologos K; Obstetrics and Gynaecology, Hull University Teaching Hospitals NHS Trust, Hull, GBR., Theofrastou SS; Obstetrics and Gynaecology, Hull University Teaching Hospitals NHS Trust, Hull, GBR., Gerovasileiou E; Obstetrics and Gynaecology, University of Thessaly Medical School, Larissa, GRC., Flynn M; Obstetrics and Gynaecology, Hull University Teaching Hospitals NHS Trust, Hull, GBR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Aug 26; Vol. 13 (8), pp. e17468. Date of Electronic Publication: 2021 Aug 26 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.17468 |
| Abstrakt: | A 73-year-old lady presented with post-menopausal bleeding and a suspicious-looking endocervical polyp. She had a loop biopsy of the cervix that showed clear cell cervical carcinoma, and she was referred to our Gynaecology oncology team for further management. Following imaging for staging and an MDT discussion, she had a total abdominal radical hysterectomy that confirmed the diagnosis. The diagnosis of clear cell adenocarcinoma of the cervix is rare, accounting for 4% of cervical carcinomas. However, it is often correlated with diethylstilbestrol (DES) exposure in utero. It is well documented that daughters of mothers who received DES during pregnancy are at a higher risk of adenocarcinomas in the genital tract. In our case, the patient had been administered DES for lactation suppression 50 years earlier. After reviewing the relevant literature, we present the case of our patient, the management of this uncommon case, and help identify possible correlation/long-term implications to patients who received DES. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Palaiologos et al.) |
| Databáze: | MEDLINE |
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