The Adipokine Component in the Molecular Regulation of Cancer Cell Survival, Proliferation and Metastasis.

Autor:	Umar MI; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan., Hassan W; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan., Murtaza G; Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan., Buabeid M; Department of Clinical Sciences, Ajman University, Ajman, United Arab Emirates.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates., Arafa E; Department of Clinical Sciences, Ajman University, Ajman, United Arab Emirates.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates., Irfan HM; Department of Pharmacy, University of Sargodha, Sargodha, Pakistan., Asmawi MZ; School of Pharmaceutical Sciences, University of Science Malaysia, Pulau Pinang, Malaysia., Huang X; College of Pharmacy, South-Central University for Nationalities, Wuhan, China.
Jazyk:	angličtina
Zdroj:	Pathology oncology research : POR [Pathol Oncol Res] 2021 Sep 13; Vol. 27, pp. 1609828. Date of Electronic Publication: 2021 Sep 13 (Print Publication: 2021).
DOI:	10.3389/pore.2021.1609828
Abstrakt:	A hormonal imbalance may disrupt the rigorously monitored cellular microenvironment by hampering the natural homeostatic mechanisms. The most common example of such hormonal glitch could be seen in obesity where the uprise in adipokine levels is in virtue of the expanding bulk of adipose tissue. Such aberrant endocrine signaling disrupts the regulation of cellular fate, rendering the cells to live in a tumor supportive microenvironment. Previously, it was believed that the adipokines support cancer proliferation and metastasis with no direct involvement in neoplastic transformations and tumorigenesis. However, the recent studies have reported discrete mechanisms that establish the direct involvement of adipokine signaling in tumorigenesis. Moreover, the individual adipokine profile of the patients has never been considered in the prognosis and staging of the disease. Hence, the present manuscript has focused on the reported extensive mechanisms that culminate the basis of poor prognosis and diminished survival rate in obese cancer patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Umar, Hassan, Murtaza, Buabeid, Arafa, Irfan, Asmawi and Huang.)
Databáze:	MEDLINE
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