Lower blood pH as a strong prognostic factor for fatal outcomes in critically ill COVID-19 patients at an intensive care unit: A multivariable analysis.

Autor: Kieninger M; Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany., Sinning A; Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany., Vadász T; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany., Gruber M; Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany., Gronwald W; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Zeman F; Center for Clinical Studies, University Medical Center Regensburg, Regensburg, Germany., Lunz D; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany., Dienemann T; Department of Surgery, University Medical Center Regensburg, Regensburg, Germany., Schmid S; Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany., Graf B; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany., Lubnow M; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany., Müller T; Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany., Holzmann T; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany., Salzberger B; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany., Kieninger B; Department of Infection Prevention and Infectious Diseases, University Medical Center Regensburg, Regensburg, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Sep 29; Vol. 16 (9), pp. e0258018. Date of Electronic Publication: 2021 Sep 29 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0258018
Abstrakt: Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects of the disease and to refine treatment strategies but also to improve clinical decision-making. For clinical decision-making in particular, prognostic factors of a lethal course of the disease would be highly relevant.
Methods: In this retrospective cohort study, we analyzed the first 59 adult critically ill Covid-19 patients treated in one of the intensive care units of the University Medical Center Regensburg, Germany. Using uni- and multivariable regression models, we extracted a set of parameters that allowed for prognosing in-hospital mortality.
Results: Within the cohort, 19 patients died (mortality 32.2%). Blood pH value, mean arterial pressure, base excess, troponin, and procalcitonin were identified as highly significant prognostic factors of in-hospital mortality. However, no significant differences were found for other parameters expected to be relevant prognostic factors, like low arterial partial pressure of oxygen or high lactate levels. In the multivariable logistic regression analysis, the pH value and the mean arterial pressure turned out to be the most influential prognostic factors for a lethal course.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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