The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
| Autor: | Labbé K; The Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA., Mookerjee S; Touro University California, College of Pharmacy, Vallejo, CA.; The Buck Institute for Research on Aging, Novato, CA., Le Vasseur M; The Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA., Gibbs E; The Buck Institute for Research on Aging, Novato, CA., Lerner C; The Buck Institute for Research on Aging, Novato, CA., Nunnari J; The Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, Davis, CA. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of cell biology [J Cell Biol] 2021 Nov 01; Vol. 220 (11). Date of Electronic Publication: 2021 Sep 29. |
| DOI: | 10.1083/jcb.202103122 |
| Abstrakt: | Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining the cellular role of mitochondrial carrier homologue 2 (MTCH2). MTCH2 is a modified outer mitochondrial membrane carrier protein implicated in intrinsic cell death and in the in vivo regulation of fatty acid metabolism. Our data indicate that MTCH2 is a selective effector of starvation-induced mitochondrial hyperfusion, a cytoprotective response to nutrient deprivation. We find that MTCH2 stimulates mitochondrial fusion in a manner dependent on the bioactive lipogenesis intermediate lysophosphatidic acid. We propose that MTCH2 monitors flux through the lipogenesis pathway and transmits this information to the mitochondrial fusion machinery to promote mitochondrial elongation, enhanced energy production, and cellular survival under homeostatic and starvation conditions. These findings will help resolve the roles of MTCH2 and mitochondria in tissue-specific lipid metabolism in animals. (© 2021 Labbé et al.) |
| Databáze: | MEDLINE |
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