Cohort profile update: the main and new findings from the SaMi-Trop Chagas cohort.

Autor: Oliveira CDL; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Cardoso CS; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Baldoni NR; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Natany L; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Ferreira AM; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil., Oliveira LC; Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Nunes MDCP; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Quintino ND; Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais, Brazil., Bierrenbach AL; Hospital Sírio-Libanês, Vital Strategies, São Paulo, São Paulo, Brazil.; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Programa de Pós-Graduação, Goiânia, Goiás, Brazil., Buss LF; Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil., Haikal DS; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil., Cunha Neto E; Universidade de São Paulo, Faculdade de Medicina, Instituto do Coração, Laboratório de Imunologia, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Divisão de Imunologia Clínica e Alergia, São Paulo, São Paulo, Brazil., Ribeiro ALP; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Sabino EC; Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2021 Sep 27; Vol. 63, pp. e75. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
DOI: 10.1590/S1678-9946202163075
Abstrakt: The SaMi-Trop project is a cohort study conducted in 21 municipalities of endemic areas of Chagas disease, including 1,959 patients with chronic Chagas cardiomyopathy. In this article we updated the results of the project, adding information from the second cohort visit. Trypanosoma cruzi-seropositive patients were enrolled from the primary care Telehealth service in Minas Gerais State, Brazil. The eligibility criterium for the second visit was the participation in the baseline evaluation. Of 1,959 participants at the baseline assessment, 1,585 (79.9%) returned after two years for the second evaluation. The mortality rate was 6.7%, but varied from 0.9% to 18.2% when it was stratified by certain clinical characteristics. A lower age-adjusted NT-Pro-BNP level (less than 300) and a prior benznidazole treatment were associated with lower mortality. There was an improvement in most quality of life domain scores. Participants have also reported fewer signs and symptoms and greater use of medication. The second follow-up visit will be complete in Oct 2021.
Databáze: MEDLINE
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