| Autor: |
Zidan SAH; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan., Abdelhamid RA; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt., Alian A; Department of Zoology, Faculty of Science, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt., Fouad MA; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Matsunami K; Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan., Orabi MAA; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt. |
| Abstrakt: |
The ethyl acetate and dichloromethane-soluble fractions, from a soft coral Sarcophyton trocheliophorum total methanolic extract, exhibited significant anti-leishmanial and cytotoxic activities. These active fractions yielded a new cembranoid diterpene ( 1 ), two known analogues [sarcotrocheliol ( 2 ) and sarcophine ( 3 )], and two sterols [(24 S )-24-methylcholesterol ( 4 ) and gorgosterol ( 5 )]. The structure of the new diterpene ( 1 ) was determined via a detailed analysis of its spectroscopic data. Compounds 3 and 5 demonstrated noticeable cytotoxicity on A549 (IC 50 17.4 ± 1.9 µg/ml) and HepG2 (IC 50 17.7 ± 1.5 µg/ml) cell lines, respectively. None of the isolates 1‒5 showed detectable anti-leishmanial activity (IC 50 >100 µg/ml). |
