The Long-term Effect of Different Exercise Intensities on High-Density Lipoprotein Cholesterol in Older Men and Women Using the Per Protocol Approach: The Generation 100 Study.

Autor:	Berglund I; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Vesterbekkmo EK; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Retterstøl K; Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway.; The Lipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway., Anderssen SA; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway., Fiatarone Singh MA; Sydney School of Health Sciences and Sydney Medical School, The Faculty of Medicine and Health, The University of Sydney, Lidcombe, Australia.; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA., Helge JW; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lydersen S; Regional Center for Child and Youth Mental Health and Child Welfare, Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Wisløff U; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; School of Human Movement and Nutrition Science, University of Queensland, Brisbane, QLD, Australia., Stensvold D; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings. Innovations, quality & outcomes [Mayo Clin Proc Innov Qual Outcomes] 2021 Sep 16; Vol. 5 (5), pp. 859-871. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).
DOI:	10.1016/j.mayocpiqo.2021.07.002
Abstrakt:	Objective: To examine whether 5 years of high-intensity interval training (HIIT) increases high-density lipoprotein cholesterol (HDL-C) concentration more than moderate-intensity continuous training (MICT) and control (CON) in older men and women. Methods: A total of 1567 older adults (790 [50.4%] women) were randomized (2:1:1) to either CON (n=780; asked to follow the national recommendations for physical activity) or 2 weekly sessions of HIIT (10-minute warm-up followed by 4×4-minute intervals at ∼90% of peak heart rate) or MICT (50 minutes of continuous work at ∼70% of peak heart rate). Serum HDL-C concentration was measured by standard procedures at baseline and at 1 year, 3 years, and 5 years. The study took place between August 21, 2012, and June 31, 2018. Linear mixed models were used to determine between-group differences during 5 years using the per protocol approach. Results: Men in HIIT had a smaller reduction in HDL-C (-1.2%) than men in CON (-6.9%) and MICT (-7.8%) after 5 years ( P =.01 and P =.03 for CON vs HIIT and MICT vs HIIT, respectively). No effect of exercise intensity on HDL-C was seen in women. Changes in peak oxygen uptake were associated with changes in HDL-C in both men and women, whereas changes in body weight and fat mass were not. Conclusion: In men, HIIT seems to be the best strategy to prevent a decline in HDL-C during a 5-year period. No effect of exercise intensity was seen for older women. Trial Registration: ClinicalTrials.gov identifier: NCT01666340. (© 2021 THE AUTHORS.)
Databáze:	MEDLINE
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