Does faecal calprotectin differentiate between inflammatory bowel disease colitis and non-inflammatory bowel disease colitides?

Autor: Khalil AF; Gastroenterology and Nutrition Division, Department of Pediatrics, Alexandria University, Alexandria, Egypt., Helmy EM; Gastroenterology and Nutrition Division, Department of Pediatrics, Alexandria University, Alexandria, Egypt., Massoud MN; Gastroenterology and Nutrition Division, Department of Pediatrics, Alexandria University, Alexandria, Egypt., Baddour NM; Department of Pathology, Alexandria University, Alexandria, Egypt., Metwally RH; Gastroenterology and Nutrition Division, Department of Pediatrics, Alexandria University, Alexandria, Egypt., Omar OM; Gastroenterology and Nutrition Division, Department of Pediatrics, Alexandria University, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Przeglad gastroenterologiczny [Prz Gastroenterol] 2021; Vol. 16 (3), pp. 219-223. Date of Electronic Publication: 2020 Nov 27.
DOI: 10.5114/pg.2020.101286
Abstrakt: Introduction: Chronic colitis is a major problem worldwide with high morbidity. Causes of chronic colitis are heterogeneous. A cut-off level of faecal calprotectin to predict inflammatory bowel disease (IBD) as a cause of chronic colitis is lacking.
Aim: To study the level of faecal calprotectin in different causes of colitis and to measure the cut-off level to differentiate between IBD and non-IBD colitides.
Material and Methods: This prospective study was conducted from June 2018 to May 2019. The study included all patients aged 2 months up to 18 years who were confirmed to have chronic colitis endoscopically and histopathologically attending the Gastroenterology Clinic at Alexandria University Children's Hospital. Faecal calprotectin level was measured.
Results: We included 110 patients. Allergic colitis was the commonest cause followed by IBD followed by infectious colitis (50.9%, 38.1% and 6.3% respectively). Faecal calprotectin above 744 µg/g could predict IBD as a cause of chronic colitis with 86.8% specificity and 66.7% sensitivity. Significant elevation of faecal calprotectin was detected in IBD patients. Faecal calprotectin was significantly correlated with C-reactive protein level and erythrocyte sedimentation rate.
Conclusions: Faecal calprotectin could predict the cause of colitis and could aid the paediatrician for early referral of patients with chronic colitis.
Competing Interests: The authors declare no conflict of interest.
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Databáze: MEDLINE
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