Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients.

Autor:	Pelled G; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. gadi.pelled@cshs.org.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. gadi.pelled@cshs.org.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. gadi.pelled@cshs.org., Salas MM; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; 59th Medical Wing Air Force, San Antonio, TX, 78236, USA., Han P; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Biomedical Research Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA., Gill HE 3rd; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Lautenschlager KA; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Lai TT; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Shawver CM; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Hoch MB; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Goff BJ; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Betts AM; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Zhou Z; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Biomedical Research Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Lynch C; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Biomedical Research Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Schroeder G; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Bez M; Medical Corps, Israel Defense Forces, Tel HaShomer, Israel., Maya MM; Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Bresee C; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., Gazit Z; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA., McCallin JP 3rd; Division of Pain Management, Department of Rehabilitation Medicine, Brooke Army Medical Center, San Antonio, TX, 78234, USA.; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA., Gazit D; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Faculty of Dental Medicine, Hebrew University, 91120, Jerusalem, Israel., Li D; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Biomedical Research Imaging Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.; Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2021 Sep 28; Vol. 11 (1), pp. 19195. Date of Electronic Publication: 2021 Sep 28.
DOI:	10.1038/s41598-021-97672-y
Abstrakt:	Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan. (© 2021. The Author(s).)
Databáze:	MEDLINE
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