Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative.
| Autor: | Omofuma OO; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland., Peterson LL; Washington University School of Medicine in St. Louis, St. Louis, Missouri., Turner DP; Medical University of South Carolina, Charleston, South Carolina., Merchant AT; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina., Zhang J; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina., Thomson CA; Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona., Neuhouser ML; Fred Hutchinson Cancer Research Center, Seattle, Washington., Snetselaar LG; School of Public Health, University of Iowa, Iowa City, Iowa., Caan BJ; Kaiser Permanente, University of California Berkeley, Oakland, California., Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California., Saquib N; College of Medicine, Sulaiman AlRajhi University, Saudi Arabia., Banack HR; School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, New York., Uribarri J; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York., Steck SE; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina. stecks@mailbox.sc.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Dec; Vol. 30 (12), pp. 2217-2226. Date of Electronic Publication: 2021 Sep 28. |
| DOI: | 10.1158/1055-9965.EPI-21-0610 |
| Abstrakt: | Background: Advanced glycation end-products (AGE) are formed through nonenzymatic glycation of free amino groups in proteins or lipid. They are associated with inflammation and oxidative stress, and their accumulation in the body is implicated in chronic disease morbidity and mortality. We examined the association between postdiagnosis dietary N ε -carboxymethyl-lysine (CML)-AGE intake and mortality among women diagnosed with breast cancer. Methods: Postmenopausal women aged 50 to 79 years were enrolled in the Women's Health Initiative (WHI) between 1993 and 1998 and followed up until death or censoring through March 2018. We included 2,023 women diagnosed with first primary invasive breast cancer during follow-up who completed a food frequency questionnaire (FFQ) after diagnosis. Cox proportional hazards (PH) regression models estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) of association between tertiles of postdiagnosis CML-AGE intake and mortality risk from all causes, breast cancer, and cardiovascular disease. Results: After a median 15.1 years of follow-up, 630 deaths from all causes were reported (193 were breast cancer-related, and 129 were cardiovascular disease-related). Postdiagnosis CML-AGE intake was associated with all-cause (HR Conclusions: Higher intake of AGEs was associated with higher risk of major causes of mortality among postmenopausal women diagnosed with breast cancer. Impact: Our findings suggest that dietary AGEs may contribute to the risk of mortality after breast cancer diagnosis. Further prospective studies examining dietary AGEs in breast cancer outcomes and intervention studies targeting dietary AGE reduction are needed to confirm our findings. (©2021 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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