Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.

Autor:	Du T; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; School of Pharmacy, China Medical University, Shenyang 110122, China., Mestre H; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA., Kress BT; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Liu G; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China., Sweeney AM; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA., Samson AJ; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Rasmussen MK; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Mortensen KN; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Bork PAR; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark., Peng W; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Olveda GE; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA., Bashford L; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA., Toro ER; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA., Tithof J; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Kelley DH; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA., Thomas JH; Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA., Hjorth PG; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark., Martens EA; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.; Centre for Mathematical Science, Lund University, 22100 Lund, Sweden., Mehta RI; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Rush University Alzheimer's Disease Center, Department of Pathology, Rush University, Chicago, IL, USA., Hirase H; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Mori Y; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark., Nedergaard M; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2022 Apr 18; Vol. 145 (2), pp. 787-797.
DOI:	10.1093/brain/awab293
Abstrakt:	Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of oedema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral oedema formation after cardiac arrest. (© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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