| Autor: |
Redruello-Requejo M; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.; Grupo USP-CEU de Excelencia 'Nutrición Para la Vida (Nutrition for Life)', ref: E02/0720, Alcorcón, 28925 Madrid, Spain., Carretero-Krug A; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.; Grupo USP-CEU de Excelencia 'Nutrición Para la Vida (Nutrition for Life)', ref: E02/0720, Alcorcón, 28925 Madrid, Spain., Rodríguez-Alonso P; Fundación Española de la Nutrición, 28010 Madrid, Spain., Samaniego-Vaesken ML; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.; Grupo USP-CEU de Excelencia 'Nutrición Para la Vida (Nutrition for Life)', ref: E02/0720, Alcorcón, 28925 Madrid, Spain., Partearroyo T; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.; Grupo USP-CEU de Excelencia 'Nutrición Para la Vida (Nutrition for Life)', ref: E02/0720, Alcorcón, 28925 Madrid, Spain., Varela-Moreiras G; Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.; Grupo USP-CEU de Excelencia 'Nutrición Para la Vida (Nutrition for Life)', ref: E02/0720, Alcorcón, 28925 Madrid, Spain.; Fundación Española de la Nutrición, 28010 Madrid, Spain. |
| Abstrakt: |
Growing evidence confirms choline as a critical perinatal nutrient. However, intake levels of choline and betaine among the Spanish fertile population remain unknown. Given their role in one-carbon metabolism with potential epigenetic effects, the aim of the present study was to evaluate the dietary intakes, their adequacy to existing guidelines and the main food sources together with other micronutrients involved in the methylation-methionine cycle (vitamin B 6 , folates and vitamin B 12 ) in women of childbearing age. The ANIBES study, a cross-sectional study of a representative sample of women of childbearing age (18-45 years, n = 641) resident in Spain, was used. The sample was divided into younger women (18-30 years, n = 251) and older women (31-45 years, n = 390). Dietary intake was assessed by a three-day dietary record by using a tablet device. Total median intakes for the total sample were 303.9 mg/d for choline; 122.6 mg/d for betaine; 1.3 mg/d for vitamin B 6 ; 140.8 μg/d for folates, and 3.8 μg/d for vitamin B 12 . The older subgroup showed significantly higher choline ( p < 0.05), betaine ( p < 0.001) and folates ( p < 0.05) intakes than younger women. Main food sources for the whole sample were meat and meat products for choline (28.3%), vitamin B 6 (25.7%) and vitamin B 12 (22.8%); cereals and derivatives (79.9%) for betaine; vegetables (20.0%) for folates. Overall intake adequacy was only observed for vitamin B 12 , with a very limited number of participants showing adequate intakes for all the other micronutrients. These results illustrate there is a relevant need to raise awareness about optimizing the status of the methionine cycle-related vitamins and cofactors in this potentially vulnerable population. |
