Clinical Evaluation of In-House-Produced 3D-Printed Nasopharyngeal Swabs for COVID-19 Testing.

Autor: Grandjean Lapierre S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., Bedwani S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., DeBlois F; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Fortin A; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Zamorano Cuervo N; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Zerouali K; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Caron E; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Morency-Potvin P; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., Gagnon S; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Nguissan N; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Arlotto P; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada., Hardy I; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., Boutin CA; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., Tremblay C; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., Coutlée F; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada., de Guise J; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of System Engineering, École de Technologie Supérieure, Université du Québec, Montréal, QC H3C 1K3, Canada., Grandvaux N; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue Saint-Denis, Montréal, QC H2X 0A9, Canada.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Sep 02; Vol. 13 (9). Date of Electronic Publication: 2021 Sep 02.
DOI: 10.3390/v13091752
Abstrakt: 3D-printed alternatives to standard flocked swabs were rapidly developed to provide a response to the unprecedented and sudden need for an exponentially growing amount of diagnostic tools to fight the COVID-19 pandemic. In light of the anticipated shortage, a hospital-based 3D-printing platform was implemented in our institution for the production of swabs for nasopharyngeal and oropharyngeal sampling based on the freely available, open-source design provided to the community by University of South Florida's Health Radiology and Northwell Health System teams as a replacement for locally used commercial swabs. Validation of our 3D-printed swabs was performed with a head-to-head diagnostic accuracy study of the 3D-printed "Northwell model" with the cobas PCR Media ® swab sample kit. We observed an excellent concordance (total agreement 96.8%, Kappa 0.936) in results obtained with the 3D-printed and flocked swabs, indicating that the in-house 3D-printed swab could be used reliably in the context of a shortage of flocked swabs. To our knowledge, this is the first study to report on autonomous hospital-based production and clinical validation of 3D-printed swabs.
Databáze: MEDLINE
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