Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women.

Autor: Baszuk P; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Stadnik P; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Marciniak W; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Derkacz R; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Jakubowska A; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Cybulski C; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Huzarski T; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland.; Department of Clinical Genetics and Pathology, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Góra, Poland., Gronwald J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Dębniak T; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Białkowska K; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Pietrzak S; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Kładny J; Department of General Surgery and Surgical Oncology, First Clinical Hospital of Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland., Scott RJ; Priority Research Centre for Cancer Research, Innovation and Translation, Hunter Medical Research Institute, New Lambton Heights, NSW 2308, Australia.; School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.; Division of Molecular Medicine, Pathology North, John Hunter Hospital, New Lambton, NSW 2305, Australia., Lubiński J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.; Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Grzepnica, Dobra (Szczecińska), Poland., Lener MR; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Jazyk: angličtina
Zdroj: Biomedicines [Biomedicines] 2021 Aug 28; Vol. 9 (9). Date of Electronic Publication: 2021 Aug 28.
DOI: 10.3390/biomedicines9091105
Abstrakt: In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in MT1B , GSTP1 , ABCB1 , NQO1 , CRTC3 , GPX1 , SOD2 , CAT , XRCC1 , ERCC2 can be used as a marker for the detection of colorectal cancer (CRC) among Polish women. A retrospective case-control study of CRC included 83 CRC cases and 78 healthy controls. From each study participant pre-treatment peripheral blood was collected for As level measurement by inductively coupled-plasma mass spectrometry (ICP-MS). We estimated the odds ratio (OR) of the association between blood-As levels and CRC using multivariable unconditional logistic regression models. A low blood-As level (0.27-0.67 µg/L) was associated with an increased frequency of CRC (OR: 3.69; p = 0.005). This correlation was significantly greater when participants carried particular gene variants: CAT , rs1001179-nonCC (OR: 19.4; p = 0.001); ABCB1 rs2032582-CC (OR: 14.8; p = 0.024); GPX1 rs1050450-CC (OR: 11.6; p = 0.002) and CRTC3 rs12915189-nonGG (OR: 10.3; p = 0.003). Our study provides strong evidence that low blood-As levels are significantly associated with increased CRC occurrence and that particular gene variants significantly enhanced this correlation however, due to the novelty of these findings, we suggest further validation before a definitive statement that the combined effect of low blood-As levels with specific gene polymorphisms is a suitable CRC biomarker.
Databáze: MEDLINE
Externí odkaz: