| Autor: |
Zhu WG; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Hibbert JE; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Lin KH; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Steinert ND; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Lemens JL; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Jorgenson KW; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA., Newman SM; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA., Hornberger TA; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. |
| Abstrakt: |
This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8-12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual's performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise. |
