Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium .
| Autor: | Ecke M; Cell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, Germany., Prassler J; Cell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, Germany., Gerisch G; Cell Dynamics Group, Max Planck Institute of Biochemistry, am Klopferspitz 18, D-82152 Martinsried, Germany. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cells [Cells] 2021 Aug 29; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 29. |
| DOI: | 10.3390/cells10092240 |
| Abstrakt: | Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|