One-step diagnosis strategy together with multidisciplinary telematics referral perform an effective approach for identifying and treating patients with active Hepatitis C infection.

Autor:	Torrecillas M; General University Hospital Consortium of Valencia, Department of Clinical Microbiology, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain., Gómez-Muñoz N; General University Hospital Consortium of Valencia, Department of Infectious Disease, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain., Ocete MD; General University Hospital Consortium of Valencia, Department of Clinical Microbiology, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain; School of Medicine, Catholic University of Valencia, Spain. Electronic address: ocete_mar@gva.es., Cuevas PR; General University Hospital Consortium of Valencia, Department of Infectious Disease, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain., Madrid MD; General University Hospital Consortium of Valencia, Department of Gastroenterology and Hepatology; School of Medicine, University of Valencia, Spain., González EO; General University Hospital Consortium of Valencia, Department of Infectious Disease, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain; School of Medicine, University of Valencia, Spain., Cardona CG; General University Hospital Consortium of Valencia, Department of Clinical Microbiology, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain; School of Medicine, University of Valencia, Spain., García-Deltoro M; General University Hospital Consortium of Valencia, Department of Infectious Disease, Avenida Tres Cruces, 2. CP, 46014 Valencia, Spain; School of Medicine, University of Valencia, Spain.
Jazyk:	angličtina
Zdroj:	Annals of hepatology [Ann Hepatol] 2022 Jan-Feb; Vol. 27 (1), pp. 100542. Date of Electronic Publication: 2021 Sep 24.
DOI:	10.1016/j.aohep.2021.100542
Abstrakt:	Introduction and Objectives: Implementation of a one-step strategy for diagnosis of active Hepatitis C virus (HCV) infection would encourage the early diagnosis and reduce the time to access antiviral treatments. The aim of this study was to evaluate the impact of a HCV one-step diagnosis compared to the traditional two-step protocol in terms of the time required for patients to be seen by specialists and the time taken to start antiviral treatment. Material and Methods: A comparative study was carried out to assess two diagnostic algorithms (one-step and two-step) for active HCV infection. Serological markers were quantified using the same serum sample to determine both anti-HCV antibodies (HCV-Ab) and HCV core antigen (HCV-cAg) by Architect i2000 SR kit. In this period, a multidisciplinary procedure was started for telematics referral of viremic patients. Results: One-step approach reduced the time required for patient HCV diagnosis, referral to a specialist, access to treatment, and eliminated the loss of patients to follow-up. Significant differences were observed between one-step and two-step diagnosis methods in the time required for patients to be seen by a specialist (18 days [Interquartile range (IQR) = 14-42] versus 107 days [IQR = 62-148]) and for the initiation of treatment (54 days [IQR = 43-75] versus 200 days [IQR = 116-388]), mainly for patients with advanced fibrosis (35 days [IQR = 116-388] versus 126 days [IQR = 152-366]). Conclusions: Use of HCV-cAg has proven to be a useful tool for screening patients with active hepatitis C. The development of a multidisciplinary protocol for the communication of results improved the efficiency of the care process. Competing Interests: Conflicts of interest There are no conflicts of interest. (Copyright © 2021 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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