Genotypic glucose-6-phosphate dehydrogenase (G6PD) deficiency protects against Plasmodium falciparum infection in individuals living in Ghana.

Autor: Amoah LE; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Asare KK; Dept. of Biomedical Science, School of Allied Health Sciences, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana., Dickson D; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Abankwa J; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Busayo A; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Bredu D; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Annan S; Dept. of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana., Asumah GA; National Malaria Control Program, Accra, Ghana., Peprah NY; National Malaria Control Program, Accra, Ghana., Asamoah A; National Malaria Control Program, Accra, Ghana., Laurencia Malm K; National Malaria Control Program, Accra, Ghana.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Sep 27; Vol. 16 (9), pp. e0257562. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0257562
Abstrakt: Introduction: The global effort to eradicate malaria requires a drastic measure to terminate relapse from hypnozoites as well as transmission via gametocytes in malaria-endemic areas. Primaquine has been recommended for the treatment of P. falciparum gametocytes and P. vivax hypnozoites, however, its implementation is challenged by the high prevalence of G6PD deficient (G6PDd) genotypes in malaria endemic countries. The objective of this study was to profile G6PDd genotypic variants and correlate them with malaria prevalence in Ghana.
Methods: A cross-sectional survey of G6PDd genotypic variants was conducted amongst suspected malaria patients attending health care facilities across the entire country. Malaria was diagnosed using microscopy whilst G6PD deficiency was determined using restriction fragment length polymorphisms at position 376 and 202 of the G6PD gene. The results were analysed using GraphPad prism.
Results: A total of 6108 subjects were enrolled in the study with females representing 65.59% of the population. The overall prevalence of malaria was 36.31%, with malaria prevalence among G6PDd genotypic variants were 0.07% for A-A- homozygous deficient females, 1.31% and 3.03% for AA- and BA- heterozygous deficient females respectively and 2.03% for A- hemizygous deficient males. The odd ratio (OR) for detecting P. falciparum malaria infection in the A-A- genotypic variant was 0.0784 (95% CI: 0.0265-0.2319, p<0.0001). Also, P. malariae and P. ovale parasites frequently were observed in G6PD B variants relative to G6PD A- variants.
Conclusion: G6PDd genotypic variants, A-A-, AA- and A- protect against P. falciparum, P. ovale and P. malariae infection in Ghana.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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