The plasticity of late-onset dementia: A nationwide cohort study in Denmark.

Autor:	Hegelund ER; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark., Mehta AJ; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark., Mortensen LH; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark., Westendorp RGJ; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Jul; Vol. 18 (7), pp. 1287-1295. Date of Electronic Publication: 2021 Sep 27.
DOI:	10.1002/alz.12469
Abstrakt:	Introduction: The determinants of the secular decline in the incidence of dementia are not clear. The aim of this study was to investigate the influences of four factors-education, wealth, cerebrovascular health, and general health-on the secular decline. Methods: A cohort study was conducted of all individuals aged ≥65 years in Denmark from 2005 through 2018 (N = 1,757,168). Annual incidence rates of dementia and population attributable risks of the four factors were calculated and birth cohort trends were examined. Results: The incidence of dementia declined by 22.5% in men and 34.2% in women from 2005 through 2018. Population attributable risks of lower education, lower wealth, and stroke likewise declined. Independent of these improvements, the incidence of dementia fell across successive birth cohorts. Discussion: Most of the observed plasticity in late-onset dementia is associated with a risk decline across successive birth cohorts that is independent of improvements in traditional risk factors. (© 2021 the Alzheimer's Association.)
Databáze:	MEDLINE
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