Involvement of RNA granule proteins in meiotic silencing by unpaired DNA.
| Autor: | Xiao H; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Vierling MM; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Kennedy RF; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Boone EC; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Decker LM; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Sy VT; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Haynes JB; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Williams MA; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA., Shiu PKT; Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA. |
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| Jazyk: | angličtina |
| Zdroj: | G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Sep 27; Vol. 11 (10). |
| DOI: | 10.1093/g3journal/jkab179 |
| Abstrakt: | In Neurospora crassa, expression from an unpaired gene is suppressed by a mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) factors to silence target mRNAs. Here, we report that Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule components, are involved in MSUD. These fungal proteins are found in the perinuclear region and P-bodies, much like their worm counterparts. They interact with components of the meiotic silencing complex (MSC), including the SMS-2 Argonaute. This is the first time MSUD has been linked to RNA granule proteins. (© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.) |
| Databáze: | MEDLINE |
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