Emergency department implementation of monoclonal antibody infusion for the treatment of coronavirus disease 2019: A template for rapid deployment.

Autor: Woltemate TJ; Department of Emergency Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Wadas RJ; Department of Emergency Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., McCreary EK; Division of Infectious Diseases, Department of Internal Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Bariola R; Division of Infectious Diseases, Department of Internal Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Minnier T; Wolff Center, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA., Marroquin OC; Clinical Analytics, University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA., Schmidhofer M; Division of Cardiology, Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Albin D; University of Pittsburgh Medical Center Supply Chain Management/HC Pharmacy University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA., Angus DC; Clinical Research Investigation and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.; University of Pittsburgh Medical Center Health System Office of Healthcare Innovation University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.; Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Yealy DM; Department of Emergency Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.
Jazyk: angličtina
Zdroj: Journal of the American College of Emergency Physicians open [J Am Coll Emerg Physicians Open] 2021 Sep 17; Vol. 2 (5), pp. e12550. Date of Electronic Publication: 2021 Sep 17 (Print Publication: 2021).
DOI: 10.1002/emp2.12550
Abstrakt: Monoclonal antibody (mAb) therapy can improve coronavirus disease 2019 outcomes when infused early in select patients. We sought to rapidly create and implement a program for emergency department (ED) mAb infusion to aid care. Using multiple strategies and actions-education, selection criteria, screening tools, rapid testing, compounding, and delivery-we infused 832 ED patients with a mAb. The screening tool identified 94.5% of these patients as potential candidates. Length of stay was nearly identical for patients who tested positive for coronavirus disease 2019 versus those requiring testing. Mild adverse reactions occurred in 2.3% of mAb infusions, and severe reactions occurred in 0.5% of infusions. We highlight a strategic approach for using the ED as a key coronavirus disease 2019 therapeutic site for this intervention and with high utility and low disruption.
Competing Interests: The authors declare no conflict of interest.
(© 2021 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.)
Databáze: MEDLINE
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