Relative risk factors for seropositive hepatitis E virus among blood donors and haemodialysis patients: The pivotal role of primary health care education.

Autor: Babiker NA; Wad Medani Teaching Hospital for Obstetrics and Gynaecology, Gezira State, Sudan., Abakar AD; Department of Medical Parasitology, Faculty of Medical Laboratory Science, Gezira University, Wad Madani, Sudan., Mohamed NT; Department of Parasitology, NPHL Research Unit, Khartoum, Sudan., Abuzeid N; Department of Microbiology, Faculty of Medical Laboratory Sciences, Khartoum, Sudan., Modawe G; Department of Biochemistry, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan., Iesa MA; Department of Physiology, Al Qunfudah Medical College, Umm Al Qura University, Al Qunfudah, Kingdom of Saudi Arabia., Assil S; Department of Community Medicine, Al Baha University, Al Bahah, Kingdom of Saudi Arabia., Osman H; Department of Gastroenterology, King's Mill Hospital, Sutton-In-Ashfield, Nottinghamshire, United Kingdom., Hamed M; Department of Gastroenterology, Inverclyde Royal Hospital, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Ahmed MH; Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, Buckinghamshire, United Kingdom.
Jazyk: angličtina
Zdroj: Journal of family medicine and primary care [J Family Med Prim Care] 2021 Jul; Vol. 10 (7), pp. 2655-2660. Date of Electronic Publication: 2021 Jul 30.
DOI: 10.4103/jfmpc.jfmpc_2441_20
Abstrakt: Background: Hepatitis E virus is a zoonotic virus with a worldwide epidemic outbreak. The aim of the study was to identify relative risk factors and co-infections concerning the seropositive HEV IgG among blood donors and haemodialysis (HD) patients in the central blood bank and renal dialysis centre in Wad Medani city, Gezira State, Sudan.
Materials and Methods: This was a cross-sectional study that included 600 participants, among them 180 showed strong seropositive HEV IgG. The structured questionnaire was used to collect data of the participants' demographics, disease risk factors and HEV IgG co-infections with HBV, HCV, HIV and syphilis.
Results: Among the 180 strong seropositive HEV IgG respondents, 84 were blood donors and 96 were haemodialysis patients. The gender and age (18-30 years) had a significant association with the virus exposure ( P = 0.000, P = 0.000). Importantly, a significant association of HEV prevalence due to the localities effect exhibited with the highest rate among South Gezira (OR = 38, CI = 14.1-107; P = 0.000). This also observed in Wad Medani, Umm Algura, East Gezira and Managil localities ( P = 0.000). The effect of the animal contact on HEV distribution exerted the significant association among the respondents for blood donors and haemodialysis patients in univariate (OR = 4.09, 95% CI 1.5-10.9; P = 0.005) and multivariate (OR = 3.2, CI = 1.1-9.4; P = 0.027) analysis.
Conclusion: The relative risk factors of the HEV seroprevalence were gender, age, locality and animal contact. Besides the need of a regular survey for the virus seroprevalence, primary health care physicians can play pivotal role in health education, especially in rural areas of Sudan. In addition, primary health care physicians in Sudan are expected to establish strategies and plans to eradicate and minimise the health impact of HEV.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2021 Journal of Family Medicine and Primary Care.)
Databáze: MEDLINE
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