A Comprehensive Review of Trichosporon spp.: An Invasive and Emerging Fungus.
| Autor: | Mehta V; Infectious Diseases, Institute of Liver and Biliary Sciences, New Delhi, IND., Nayyar C; Clinical Microbiology, Medanta SN Superspeciality Hospital, Sriganganagar, IND., Gulati N; Clinical Microbiology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND., Singla N; Microbiology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND., Rai S; Preventive and Social Medicine, Government Medical College, Patiala, Patiala, IND., Chandar J; Clinical Microbiology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Aug 21; Vol. 13 (8), pp. e17345. Date of Electronic Publication: 2021 Aug 21 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.17345 |
| Abstrakt: | Trichosporon species are basidiomycetous yeast-like organisms found ubiquitous in nature. They are increasingly been recognized as opportunistic pathogens capable of causing life-threatening invasive diseases (trichosporonosis), especially in immuno-suppressed patients and rarely in immuno-competent patients too. Earlier multiple members of the genus Trichosporon were clubbed together as T. beigelli but after the advent of molecular techniques, more than 50 different subspecies and around 16 different strains causing human diseases are reported. It is known to cause a wide range of diseases, from superficial to probable and proven invasive diseases to summer hypersensitivity. The ability of Trichosporon strains to form biofilms on implanted devices, glucuronoxylomannan in their cell walls, and production of proteases and lipases lead to the virulence of this genus. This ubiquitous fungus exhibits intrinsic resistance to echinocandins, variable minimum inhibitory concentrations (MIC) for amphotericin B, and moderate susceptibility to fluconazole and Itraconazole, which are the commonly used anti-fungal agents for any invasive fungal infections which lead to the re-emergence of this notorious yet neglected pathogen and hence the reports of breakthrough infections among patients receiving these antifungals. This review is to understand the epidemiological, clinical details, and antifungal susceptibility pattern of various Trichosporon infections and it highlights the importance of early detection and treatment for this emerging yeast and also will add to the ongoing surveillance for the anti-fungal susceptibility pattern for this fungus. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Mehta et al.) |
| Databáze: | MEDLINE |
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