MFN2 Stabilization: A Bridge for Endoplasmic Reticulum Stress Sensitivity in Melanoma.
| Autor: | Adelmann CH; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rachmin I; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Fisher DE; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: dfisher3@partners.org. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of investigative dermatology [J Invest Dermatol] 2021 Dec; Vol. 141 (12), pp. 2782-2784. Date of Electronic Publication: 2021 Sep 23. |
| DOI: | 10.1016/j.jid.2021.05.003 |
| Abstrakt: | In a new article in the Journal of Investigative Dermatology, Wang et al. (2021) report that mitochondrial quality control modulates responses to endoplasmic reticulum (ER) stress in melanoma. They implicate a linear pathway of XBP1, MARCH5, and MFN2 that act together to regulate mitochondrial fission and mitophagy and ultimately mediate melanoma cell sensitivity to ER stress. This work informs therapeutic combinations and biomarker strategies for targeting melanoma organellar homeostasis as well as for life‒death decisions. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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