Steady state evoked potentials indicate changes in nonlinear neural mechanisms of vision in sight recovery individuals.

Autor: Pitchaimuthu K; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany. Electronic address: kabilan.pitchaimuthu@uni-hamburg.de., Dormal G; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany., Sourav S; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany., Shareef I; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany; Child Sight Institute, Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, 500 034 Hyderabad, India., Rajendran SS; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany; Child Sight Institute, Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, 500 034 Hyderabad, India., Ossandón JP; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany., Kekunnaya R; Child Sight Institute, Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, 500 034 Hyderabad, India., Röder B; Biological Psychology and Neuropsychology, University of Hamburg, Von-Melle-Park 11, 20146 Hamburg, Germany.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2021 Nov; Vol. 144, pp. 15-28. Date of Electronic Publication: 2021 Aug 21.
DOI: 10.1016/j.cortex.2021.08.001
Abstrakt: Humans with a transient phase of congenital pattern vision deprivation have been observed to feature prevailing deficits, particularly in higher order visual functions. However, the neural correlates of these prevalent visual impairments remain unclear. To probe different visual processing stages, we measured steady state visual evoked potentials (SSVEPs) generated by luminance flicker stimuli at 6.1 Hz, with superimposed horizontal periodic motion at 2.1 Hz or 2.4 Hz. SSVEP responses at the fundamental and second harmonic of luminance flicker frequency, and at their intermodulation frequencies with motion information, were analyzed. Three groups were tested: (1) 15 individuals who had suffered a lack of pattern vision from birth due to the presence of bilateral total congenital cataracts (CC group), which were surgically removed between 4 months and 22 years of age, (2) 13 individuals with reversed developmental i.e., later developing cataracts (DC group), and (3) normally sighted control participants (SC group; n = 13) matched in age and sex to the CC individuals. SSVEPs at the second harmonic frequency (i.e., 12.2 Hz) and at the intermodulation frequencies (8.2 Hz, and 8.5 Hz) were attenuated in the CC group. In contrast, fundamental frequency responses (i.e., at 6.1 Hz) were not significantly altered in the CC group compared to the control groups (SC and DC groups). Based on previous evidence on the role of striate vs. extrastriate generators of fundamental vs. second harmonics of SSVEPs, these results provide evidence for a stronger experience dependence of extrastriate than striate cortical processing, and furthermore, suggest a sensitive period for the development of putative nonlinear neural mechanisms hypothesized to mediate visual feature binding.
Competing Interests: Declaration of competing interest The authors declare no competing financial interests.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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