Interoception and alcohol: Mechanisms, networks, and implications.

Autor: Lovelock DF; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine, USA., Tyler RE; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, School of Medicine, USA., Besheer J; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, School of Medicine, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, School of Medicine, USA; Department of Psychiatry, University of North Carolina at Chapel Hill, School of Medicine, USA. Electronic address: joyce_besheer@med.unc.edu.
Jazyk: angličtina
Zdroj: Neuropharmacology [Neuropharmacology] 2021 Dec 01; Vol. 200, pp. 108807. Date of Electronic Publication: 2021 Sep 23.
DOI: 10.1016/j.neuropharm.2021.108807
Abstrakt: Interoception refers to the perception of the internal state of the body and is increasingly being recognized as an important factor in mental health disorders. Drugs of abuse produce powerful interoceptive states that are upstream of behaviors that drive and influence drug intake, and addiction pathology is impacted by interoceptive processes. The goal of the present review is to discuss interoceptive processes related to alcohol. We will cover physiological responses to alcohol, how interoceptive states can impact drinking, and the recruitment of brain networks as informed by clinical research. We also review the molecular and brain circuitry mechanisms of alcohol interoceptive effects as informed by preclinical studies. Finally, we will discuss emerging treatments with consideration of interoception processes. As our understanding of the role of interoception in drug and alcohol use grows, we suggest that the convergence of information provided by clinical and preclinical studies will be increasingly important. Given the complexity of interoceptive processing and the multitude of brain regions involved, an overarching network-based framework can provide context for how focused manipulations modulate interoceptive processing as a whole. In turn, preclinical studies can systematically determine the roles of individual nodes and their molecular underpinnings in a given network, potentially suggesting new therapeutic targets and directions. As interoceptive processing drives and influences motivation, emotion, and subsequent behavior, consideration of interoception is important for our understanding of processes that drive ongoing drinking and relapse.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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