Data on Safety of Intravaginal Boric Acid Use in Pregnant and Nonpregnant Women: A Narrative Review.

Autor:	Mittelstaedt R; From the Department of Internal Medicine., Kretz A; Medical School, Johns Hopkins School of Medicine, Baltimore, MD., Levine M; Department of Emergency Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA., Handa VL; Department of Gynecology and Obstetrics., Ghanem KG; Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD., Sobel JD; Division of Infectious Disease, Wayne State University, Detroit, MI., Powell A; Department of Gynecology and Obstetrics., Tuddenham S; Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD.
Jazyk:	angličtina
Zdroj:	Sexually transmitted diseases [Sex Transm Dis] 2021 Dec 01; Vol. 48 (12), pp. e241-e247.
DOI:	10.1097/OLQ.0000000000001562
Abstrakt:	Abstract: Intravaginal boric acid (IBA) represents one of the only options available to treat azole-resistant vulvovaginal candidiasis (VVC) and is included as part of multiple national guidelines (including the United Kingdom and the United States) for the treatment of VVC or recurrent bacterial vaginosis. Novel products using IBA are under development for treatment and suppression of VVC and bacterial vaginosis. Use of over-the-counter or clinician-prescribed IBA in reproductive-aged women is already widespread and may increase further if drug resistance in VVC rises. However, IBA is not a Food and Drug Administration-approved drug, and safety data are sparse. Given these factors, it is important to understand the currently available data on the safety of IBA use. Herein, we set out to synthesize human and animal data (converting, where appropriate, dose and serum values to standard units to facilitate comparison) to answer 2 key questions: (1) What are the data on the safety of IBA use for women? and (2) What are the data on the safety of IBA use in pregnancy? We find that, despite gaps, available data suggest IBA use is safe, at least when used in doses commonly described in the literature as being prescribed by clinicians. Information on harms in pregnancy is limited, and data remain insufficient to change current guidelines, which recommend IBA avoidance in pregnancy. Competing Interests: Conflict of Interest and Sources of Funding: S.T. has been a consultant for Biofire Diagnostics, Roche Molecular Diagnostics, and Luca Biologics; receives royalties from UPTODATE; and has received speaker honoraria from Roche Molecular Diagnostics and Medscape. S.T. is supported by the National Institutes of Health (grant K23AI125715). A.P. receives royalties from UPTODATE. J.D.S. has served as a consultant to Scynexis Pharma and Mycovia Pharmaceuticals. (Copyright © 2021 American Sexually Transmitted Diseases Association. All rights reserved.)
Databáze:	MEDLINE
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