Production and characterization of monoclonal antibodies to Bacteroides gingivalis.

Autor: Simonson LG, Merrell BR, Rouse RF, Shklair IL
Jazyk: angličtina
Zdroj: Journal of dental research [J Dent Res] 1986 Feb; Vol. 65 (2), pp. 95-7.
DOI: 10.1177/00220345860650021801
Abstrakt: The rapid detection of Bacteroides gingivalis by immunological methods using monoclonal antibodies could greatly improve the diagnosis and prognosis of severe periodontal disease in adults. In this study, three distinct hybridomas were produced which secrete monoclonal antibodies to soluble and whole-cell antigen preparations of B. gingivalis. The BGII, V F9/2D hybridoma produced a murine antibody that can detect all of the B. gingivalis isolates studied while never cross-reacting with the other oral microbial antigens tested.
Databáze: MEDLINE